Determinants of response to CAR T cell therapy in a multicenter, multi-trial cohort analysis of patients with lymphoma

Synopsis

Nature Medicine, Published online: 23 October 2026; doi:10.1038/s41591-026-04707-w A large comprehensive analysis of clinical trial samples from patients with non-Hodgkin lymphoma who were treated with anti-CD19 CAR T therapy shows that a high proportion of naive-like and stem cell memory-like CCR7+CD45RA+ T cells in the pre-infusion CAR T product correlates with improved and prolonged clinical benefit, which was validated in an independent external cohort including different products.

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