Next-generation immune cell engagers for B cell depletion in autoimmune diseases

Synopsis

Nature Reviews Drug Discovery, Published online: 07 October 2026; doi:10.1038/s41573-026-01534-z Immune cell engagers are emerging as a strategy for deep B cell depletion in autoimmune diseases. This Review examines their mechanisms, clinical development and next-generation designs, including T cell, natural killer cell and γδ T cell-engaging formats, and considers lessons from haematological malignancies to improve efficacy, safety and durability of immune modulation.

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