Translating base editors: a decade of progress from the bench to the clinic

Synopsis

Nature Reviews Drug Discovery, Published online: 16 October 2026; doi:10.1038/s41573-026-01548-7 Base editing, a gene editing technology capable of installing point mutations with high efficiency and precision, was first reported a decade ago. This Review examines the evolution of base editors and their road to clinical translation, highlighting key advances, ongoing challenges and the current clinical trial landscape.

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